This database provides the list of non-coding cancer drivers in gene promoters, enhancers, ncRNAs and CTCF-cohesin insulators published in over 25 studies. We applied text mining and manual curation to PubMed articles and then developed CNCDatabase, Cornell Non-Coding Cancer driver Database. CNCDatabase provides a helpful resource for researchers to explore the pathological role of non-coding alterations and their associations with gene expression in human cancers. You can also read about it at Liu et al. 2020.
CNCDriver is a method designed to consider mutational recurrence, functional impact and mutational co-variates to identify coding and non-coding cancer driver mutations from whole-genome sequencing data. The source code of CNCDriver is available at CNCDriver, and the details of this method can be found at Liu et al. 2019.
Computational method to identify tumorigenic drivers using the combined effects of coding and non-coding single nucleotide variants, structural variants, and DNA methylation changes in a DNase I hypersensitivity based regulatory network. RegNetDriver is available at RegNetDriver, and more information can be found at Dhingra et al. 2017.